Addison’s Disease: Causes, Symptoms and Treatment

Addison’s disease is an endocrine disease that majorly affects dogs.  Also known as hypoadrenocorticism, Addison’s disease happens due to under functioning of adrenal glands. Adrenal glands secrete hormones – mineralocorticoids, androgens and glucocorticoids that are highly important for sustaining life. The glucocorticoids regulate metabolism of protein, fat and glucose whereas mineralocorticoids help in regulating electrolytic balance, blood pressure and extracellular fluid volume.  When these functions are not carried out properly, it causes Addison’s disease. 


Causes Of Addison’s Disease

·        Immune-mediated destruction of adrenal tissue
·        Infection or trauma of adrenal glands
·        Treatment of Cushing’s disease which can suppress the production of cortisol and aldosterone
·       Secondary form of Addison’s disease can occur due to defect in the pituitary gland function or tumor
·        It can also occur due to long term treatment using steroids
·      Vulnerability of the breed to this disease. For instance, Bearded collie, Nova Scotia duck tolling retrievers, Labrador retrievers and leonbergers are more likely to contract this disease compared to other dog breeds.

Symptoms of Addison’s Disease 

Addison’s disease is very difficult to diagnose but certain symptoms can definitely indicate the presence of the disease. These may include:

·        Loss of Appetite
·        Gastroenteritis
·        Depression
·        Lethargy
·        Weight Loss
·        Diarrhea
·        Dehydration
·        Pain in abdomen
·        Hypoglycemia
·        Vomiting
·        Low temperature
·        Hyper pigmentation

Diagnosis of Addison’s Disease

A vet generally recommends blood work after examining the symptoms. In addition, ACTH stimulation test is also conducted to check the imbalances in the cortisol levels. ECG, abdominal ultrasound or radiograph can also be performed to figure out the cause of the symptoms. MRI and CT Scan can also be conducted to check any functional issues with the pituitary gland as well.

Treatment of Addison’s Disease

Percoten-V is normally used to treat Addison’s disease in dogs. These injections are taken every 3-4 weeks and eliminates the deficiency of mineralocorticoid aldosterone and glucocorticoid.
At times, oral treatments are also recommended for curing the disease. The prognosis may include follow-up testing and monitoring of the cortisol levels. Other than that, the vet may also perform regular check-ups.

Addison’s disease is debilitating and can take a pet’s life and hence must be treated without delay. Though pet parents only get to know about this disease when their pet suffers from Addison crisis but if treatment is given on time, it can be definitely cured.

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